My throttle didn't brick, at least now yet, but it's been plugged in for over two years without problems. Yesterday it took ages to get past the POST screen, it halted for minutes during "initializing USB controllers". Keyboard was sluggish as hell but once I got to Windows, everything seemed fine. Unplugging the throttle solved the slow boot problem.
Then I ran a configuration file. Windows started searching for a HID driver for the throttle which it couldn't find. Clicking "Get firmware" from TARGET crashed it.
I uninstalled drivers, installed them again, reflashed the firmware with the same, newest version it already had. Problem solved, for now :geek: