Nope, this is normal. ED disabled SSAA setting for resolution above 1080p, or maybe 1440p, can't remember. Keep in mind that SSAA is a "brut" antialiasing method, basically it you choose 2x, it will render the image at 2x your native resolution, you have a 4K monitor, do the math, your graphic card will have a hard time. Maybe the better solution for you is to enable FXAA through Nvidia Control Panel (a bit blurry but almost no performance hit) or try the SMAA injector with Reshade https://reshade.me, wich is not that bad.