I use the takeoff and combat panels in vr currently, and they work fine without using the app, they just use lighting and switch positioning, I do have to pre-flight the panels. The ddi/ufc might require more data to work... So it's difficult to judge blind, but in 2d yes it should be manageable but possibly some display latency will take place etc... I did use the app to initially configure the panels and then left them alone.
There is even a specific bundle for VR in the prices quoted, so I would think so, in VR they don't have the screens for the ddi, so they are just USB button boxes at that point