Did you install driver for joystick prior to programming software? In my case profiler is not even starting. I though maybe it is related to the driver, but when I tried to install driver, it didn't even detected my joystick.
I tried two different versions, but result is the same
X52_HOTAS_x64_8_0_132_0
X52_HOTAS_x64_8_0_213_0