@Loopyllu1 I'm also having this issue. I've removed and reinstalled the software exactly as the video from @ctytler explains in his 2020 video https://www.youtube.com/watch?v=RPKnp6PJU7U&t=318s I am not using Ikarus so the port was changed to 1725 per the instructions.
I did try running in admin mode as well, but according to @EbonySeraphim that isn't needed. I keep getting this DCS Comms error where it's not detecting DCS while the simulator and Stream Deck are running, however Stream Deck is detecting the modules I have installed with ID Lookup.
Anybody have any suggestions?