I built myself a simple .cmd file that uses pre-set .lua config files to change the settings in DCS as to my choice as I only have one installation of DCS (Open Beta). I also use it to set sound device and volume (with nircmd) and to start other necessary programs that I want in conduction with DCS, like TrackIR, VoiceAttack and DCS Simple Radio. I also have a line in it to change the .lua file for my Joystick as I want to have the same Zoom buttons in VR (for muscle memory reasons) as I have when I am flying with Track IR. When I select a Track IR option, the VR-joystick file is removed so the basic Zoom settings in Control apply again (and not VR Zoom in UI Layer).
I have attached it so use if you like. Paths etc. has to be changed ofc. as they are related to my config/setup. The .cmd file resides in Saved Games/DCS.openbeta/Config directory and I have made a shortcut to it on my desktop.
Slo-Mo's post in Seperate VR and non-VR Desktop Icons? was marked as the answer