For the record, as I have been following for awhile but hadn't posted. I'm running the below USB devices. The hubs are required due to control locations vs PC location and a powered hub for my VR headset as it glitches out off mobo power.
USB3 Hub
Virpil MongoosT-50CM2 Stick
Virpil MongoosT-50CM2 Throttle (3 devices)
Saitek Combat Flight Pedals
USB3 Hub
Samsung Odyssey+ WMR VR Headset
Keyboard
Mouse
Front panel Card reader
Datacolor Spyder5 (monitor colour calibration)
External HDD