Hi. I've got what I believe to be the same issue, but with Warthog. I changed my CPU and upgraded RAM.
I've attached screens of the problem. First dialog says activation is broken, 2nd asks for serial number (it's already filled out, but double checked anyway). It doesn't activate and loops round and round. In fact the whole dialog is shaky - the Exit button is dead, clicking Other for non-internet activation simply brings up another copy of the same dialog box and trying to de-activate tells me I just can't because activation is invalid, lol. Interestingly if you click Exit enough times the game will load in the background and will load what appears to be an unflyable demo, with the activation window still at the front. Exiting DCS at this point results in a CTD.
Sent an email to support yesterday but dead keen to get on it as have tomorrow off work! :helpsmilie: