Hey Greg i have a similiar setup but the difference is that i have the fourth monitor on top, not the bottom. now im running 3 monitors in nvidia surround at 5760x1080 and the fourth one is running at 1366x768, now i have everything working but there is one issue that makes it unplayable, my mouse pointer is horribly off for example if i want to flip a switch then i have to move my mouse way below that certain switch to flip it, would you happen to know why it is so off? and please excuse me for anything i do wrong on the forums because i am fairly new to them.