I'm running Pico 4 via Virtual Desktop on a 10900K, 4070, and 64 GB of 3200 MHz DDR4.
Yesterday I did a fresh Windows 11 install and was setting up DCS and other things. I fired up the Hornet "free flight" mission, because that's a known "benchmark" to me for testing VR, and I was getting the expected 80-90 FPS. I then fired up the F-4E "takeoff" instant action mission (the one right above free flight), and virtual desktop crashed completely while loading the world. I tried again and got the same result.
Sounds like a very similar issue and a very similar direct comparison to another module. I expected the F-4 to be heavy of course, but running at all would be a good start.