No, im not running proton, I'm using the following
CPU: 5700X3D
GPU: 6700xt 12gb VRAM
32GB ram, with 64GB swap (large swap to keep the game "steady" for multiplayer)
Wine: wine-lutris-GE-proton8-26-x86_64
DXVK: dxvk-2.3.1
And it's running pretty smoothly besides the entire VRAM being filled when playing in multipler (that really needs to be resolved to leave the system at LEAST 1-2gb free for the system to operate properly)