A retired USAF buddy of mine who has his 1,000 hour patch for the A-10 (granted circa 1980's), says they routinely flew with only one 65 under each wing and that's it. Their primary weapon back then was considered to be the gun as their primary mission back then was killing Russian tanks heading for the West German board en masse. Anything more under the wings and they would lose speed and maneuverability. So it was blast off, shoot two mavs, go to the gun, RTB when empty, and do it all again after hot re-arm and re-fuel. Granted, the scope of the mission and capability of the aircraft have changed.
So naturally flying with a wider assortment of ordnance under the wings while sacrificing performance is more routine today. That being said, flying a bomb-truck at max gross weight with every ordnance configuration possible under the wings is highly unrealistic. A balance of a couple of Mavs, a couple of bombs whether guided or unguided, and a good load of fuel is realistic.