I don't have that problem with my X52 Pro, and i doubt the profile is the problem unless you changed the throttle to work as bands or something else.
Double check the axis assignments... maybe try clearing every assignment for the controller and check if you might have anything else bothering (TrackIR, Mouse, other controllers, etc.). Then reassign them and check if you see the twitching in the Axis Tune screen.
Also, just in case, try connecting the controller on a different USB port and repeating the tests again.
If you wish i can provide you with my profile but i really doubt that's the issue (also, if you don't have a TrackIR you will need to modify it since i'm using all HAT Switches for different buttons)