I, like most people here, have lots of time in various simulators, and love to fly helos in DCS, X-Plane and so on. I also have a glider PPL and about 300 hours. When I tried a helicopter I found that I had no problem whatsoever flying it straight and level, turning etc - not surprising, considering it controls like an airplane except with less pedal input in turns. Hovering was another matter, I could hold it within about a 10-20 foot circle, but that's nowhere near enough to land without tipping it over or breaking something important. Still, the instructor did put his hands and feet up to show the people on the ground that it was me hovering, and I think I'd have a head start if I tried to get a PPL-H today, not least because the sim really helps you understand what's going on, what systems do what and so on.
That said, flying any amount of hours in a simulator won't teach you the necessary stick-and-rudder skills to safely operate an aircraft, but it'll give you a better idea of what's going on that if you had never seen the inside of a virtual aircraft.