IRL it is possible if an outer source (f.e. ground troops, other units, planes, choppers, etc. if they are equipped with the proper marking and targeting system, and o.c. with a secure data transfer channel) marks the target for the 'weapon carrier' plane/chopper.
A longer read including a longer answer for this question and future proposals >
http://www.airpower.maxwell.af.mil/airchronicles/cc/neuenswander.html
In LO you have to edit the 'requirements' of the air-to-ground munition, in the MEinit.xml file, and then you aren't forced to use a targeting pod.