Why don't you try it yourself? It depends on what SLI rendering mode the profile is using. For example, even though there's an official profile for LockOn, SLI doesn't work becasue the rendering mode is set to Single GPU.
If you have nHancer installed, you can check what mode the profile is using. If it's set to anything other than Single, SLI should work. Anyway, SLI works with DCS when I use my custom profile. I'll check with the official profile when I got home and report back.