So, the following happened (or not, depends): I reinstalled DCS completely, also SteamVR (because that behaved edgy as well) and got the latest nVidia update (Game Ready).
DCS runs marginally better. The first Quick Mission created is no issue, the mission generation briefly gives me a short freeze / CPU peak, then I can launch the flight. This also works normally and quick. I complete the flight, quit to menu and reselect the given quick mission. I generate it with the same airfield to start at, it will also allow that but loading the flight then freezes the game solid. I've sent the readouts via the crash reporter several times now, also with more or less the same explanation as above. Mind that this is without the 2H21 patch for W10 ! Also after restarting DCS I experienced the stutter / half-image issue when rotating the camera in F2-view or when turning the head in the cockpit. Very strange. To me it seems like some improper dump of the previous data set, some memory leak maybe since it only occurs after one flight is completed (which is most probably still cached).
Hopefully this can be resolved easily until the Hind goes live. Not only because the constant restarts are a hassle, also the performance is deteriorated.