Like you, it would not run for me when my desktop was 5040 x 1050, but I saw someone else had luck turning down their desktop but still running the game at 5040 x 1050, so I tried it. Clean install, set the desktop to 3840 x 768, put the game at 5040 x 1050 and started it up. I was worried as the game has long load times, but it worked. Flying fine now at 5040 x 1050. Had to adjust the max FOV so my face wasn't against the HUD.
Still one issue left. The selection screen (Campaign, Quick Mission, Options, etc...) still runs at a resolution that cuts off the exit button. Can't figure it out..... Still nice to have the higher res in the rame and the second time the option screen comes up it loads at full resolution (i.e. after flying one mission)