Yes, I'm currently on Radeon version 21.6.1 which is the most recent non-optional driver. I tried the optional driver as well, but had many issues with transparent and semi transparent textures in other titles. When I rolled back I did a complete fresh install of the driver.
I'm definitely not on a CROSSFIRE setup. I'm not sure if it makes a difference, but I am running 3 monitors, 1 as my main game display in 2k, and 2 for web browsers and other apps in 1080p.