Ok, I have some new information concerning my strange X52 problem.
When I start up my computer, I open up the Saitek Profiler and then I select the control panel. As of now, the 3 buttons I mentioned do not work, BUT! Last time I just started to press the POV2 in a circular motion and after some time, about 10 rounds, the buttons started working, all three of them. The strange thing is that I have to do this every time I start my computer.
I really have no clue to what this could be.
I'm running Vista x64 with the latest saitek drivers.