It really depends on the direction AND THE INTENSITY of the wind. Airplanes have a tailwind component limitations during take offs and landings. Which also means that with light tailwinds they can achieve any take off and landing safely.
Now, there are some airports, and some runways that may have a fixed configuration on landings and take offs until the tailwind component goes over a certain amount. I.E, some civilian airports keep the same runway in use, even with a tailwind component if it's 10kts or less. Madrid Barajas, for instance; or Tel Aviv... I think the real "Sochi" has an issue about that too.
The reason may be the fisics of the airport, it's sorrounding terrain, or ATC issues.
Anyway, talking about DCS, I'm afraid that IA ATC always uses the same runway in use regardless of the wind.