I DID print the manual (I over-estimated how many pages I would get out of my ink cartridges so I figured I could crank it out without too much difficulty, and I didn't take in to account how many screenshots there are of the ABRIS in it, which takes it up a huge amount of ink). Needless to say ... my advice is DON'T try it or you will spend like $100 in ink to print it. If you want a hard copy I would suggest you wait for them to release a hard copy and buy it. Or, if you don't want a black and white copy, take it to Kinkos to be printed or to lulu.com
And I DID read the whole thing. IMHO you pretty much HAVE to if you intend to get the most out of it. Granted some parts you don't need to read in depth. For example if you have no intention of changing ABRIS routes mid-flight you can kinda glaze over it. For the most part, however, you will need to read through it eventually.
This is a MAXIMUM fidelity sim. It is going to require study and patience and lots of practice. You cannot simply expect to jump in this bird and get going with no effort.
If you are already used to other complex flight sims that have fairly realistic physics modeling then once you get past learning the on-board systems it shouldn't be too bad.
I read through the manual over a week or two, then developed my own startup checklist and only then did I try a few test hops getting a feel for the handling. Once I got the basics down I sat down and figured out the best control mapping for my stick and throttle, etc. After only about 5-10 hr of flight time fully set up I managed to land on the helipad of Oliver H Perry destroyer on my first attempt.
The bottom line is you will find it a LOT easier and less frustrating if you have some patience and take your time to learn the systems, then learn how to handle the chopper, and only then start tackling the higher functions.
As always ... post whatever questions you have on the forums as I'm sure everyone is more than willing to help.
As for the AP ... leave all 3 autopilots (heading, pitch, attitude) on for now. Later you may want to start trying turns with heading hold off but right now you just need to be concerned with the basics.