I like the idea of a strategic airlifter, something along the lines of the AN-124,IL-76/C-17,C-5. I think they'd provide a new and interesting challenge.
May not be to everyone's taste. However the thought of airdropping supplies, vehicles and paratroopers sounds interesting to me.
As for pilotable commercial airliners, I really don't see the point, maps are too small even to really support a medium sized airliner, and I guess this is the reason why the only commercial aircraft we have is the YAK-40.