No problems that I can see.
Just remember that if you create a new Preset, that file will stay in the game's bin folder when you deactivate the ReShader. I don't believe that file sitting in the bin file will be effected by Updates or Repairs.
FYI, YoYo's Preset is included in this JSGME version, so that Preset will "come and go" as the Reshader mod is activated/deactivated.
You can Cut/Paste new presets into the JSGME mods bin folder if you want to keep everything together. Just make sure the mod is deactivated before you do so.