Sorry for the late response. :]
The AMD motherboards have a lesser degree of automation in overclocking. Its is more of an old school hands on experience guessing trial and error. You have to control the parameters more directly (for example, memory sub-timings).
Rules of thumb:
1-Be mindfull what each timing does, if you feel you can't master it all leave those on auto.
2-Do overclocking by the book. Be methodical. otherwise you will be clueless if something goes wrong.
3-Be conservative, know where the hardware is hitting the limits and drop a notch (dont chase after the mythical 4Ghz barrier if voltages and temperatures are spiking)
4-Dont skinp on the PSU and choosing the right memory kits is paramount.
I frequented forums and saw people mistyping voltages, trying to flash Zipped files or are using the wrong type of memory for overclocking etc. Most have an Intel overclocking background and are spoiled by automation (example: memory XMP profiles).
90% of the people shouldn't be allowed to mess in there TBH. This is where most of the horror stories come from.
If you are uncomfortable with overclocking just go for a B350 board with a X CPU (1600X, 1800X)
I've had no problems whatsoever with the crosshair VI and each BIOS iteration has allowed me to up a notch on my overclocking and stability.