Yes, naturally. The activation is tied to your hardware, so anytime you perform major hardware changes, the current activation expires. If you don't want this to happen, please use the option to deactivate your modules prior to fiddling with your hardware. The process is outlined in the quickstart manual if you are unsure how to accomplish a deactivation.
In my opinion, SF AAA is the least intrusive and troublesome DRM scheme i have come across in the last 10 years, period. One can run into trouble when not deactivating, but apart from that, i find that it does not interfere at all with the rest of my system and it works as advertised. Not to forget, other DRM solutions have their fair share of problems.