Run the TARGET script editor (the icon without the little yellow stars). Click the Menu button, then click Open. Navigate to the location where the tmc file is and select it. Now click the green Run button. Assuming there are no errors, you are ready to start DCS and assign the axis, then fly.
This is general information. Without seeing the profile, I don't know if there is anything, other than axis assignments, that you will need to do inside of DCS before you are ready to fly.
EDIT: Note that TARGET must stay running while you play a game/sim.