I tried unsuccessfully to get into profiles with my X52, in the end I gave up and deicide just to bind in the game itself, it works perfectly and even redoing my entire A10 controls after a reinstall etc only takes me a few minutes.
Yeah you cant use modes, but to be honest with button 6 as a shift key I dont need them.
A10C is my most complex set up and I have every control I need mapped to the stick and throttle buttons etc quite nicely.
The rest of the planes are a minute or 2 to set up, I really enjoy doing them to be honest.