Please note the "General" category is not used by any aircraft. They each have their own category(ies). So if you have a controls issue with, say, your F-16C module, check controls in the "F-16C" category.
If you've already checked your aircraft categories as well, start by running DCS with no devices other than the keyboard and mouse, and see if the issue persists.
If the issue is gone, plug back your devices one by one.