So not sure how you’ve ended up with both weapons on 1 side of the jet, but in that instance yes you’ll need to trim.
once the gear is down, you’re now into a different DCS engineered drag scenario that means different trim is required. Same for on the runway, DCS drag will affect you harshly with an asymmetric loadout. Rudder during 13deg AOA aero braking helps and then independent wheel braking until below 60kts, then NWS