Yes, There is clearance if you don't put a fan on top which is not needed with all the other fan options. Of course you could modify the top to fit a fan up there which a friend of mine did, but probably overkill.
I have 4 large fans, two front, two back in push/pull. They are quiet as well. Also, I use a Noctua Air Cooler on the CPU.
Be sure to get the grid top, not solid.
Heat problems are no issue with this case.
With the grid on all sides, the lighting on fans and components show nicely.